Beautiful Chemistry: Hoye's HDDA + Napth Trap
Every so often, a reaction behaves so well that you just publish the crude NMR spectrum.
Professor Tom Hoye's HDDA* reaction, first reported in 2012, apparently fits the bill rather well, wouldn't you say?
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| From Org. Lett. 2015, ASAP. |
Amazing - heat up a heavily conjugated triyne for 2 days, and it just does one thing, reproducibly and immaculately. I wonder whether Hoye and his group have any further tricks up their sleeve to try and control the diastereo enantioselectivity of that sweet new quaternary center...time will tell.
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*Please allow me touch of professional jealousy - this reaction opened up so many different questions for the Hoye group that they've published 10 manuscripts on it in just the last 3 years. Damn.
